




OptiAge Level 1
OptiAge Level 1 provides the key nutrients needed for combating the effects of aging at the cellular level. Clinical research shows that having better vitamin D status is correlated with longer telomeres, which are a marker of biological aging. Trans- Resveratrol activates anti-aging genes called sirtuins that have been associated with greater lifespans in many organisms. 5-methyltetrahydrofolate and green tea leaf extract support DNA health through increased methylation and reduced free radicals.*
The four key ingredients to staying younger and healthier for longer
Creams and serums may reduce your visible aging. But to really improve your longevity and health you need four essential ingredients:1. Vitamin D3: Promotes longer telomeres. Shorter telomeres are a marker of your biological aging. In one study, Vitamin D was shown to reduce telomere aging equivalent to five years.*
2. Trans-resveratrol: Activates sirtuins – your anti-aging genes. Sirtuins are associated with greater lifespans in many organisms – in some cases up to 70%. What's more, Trans-resveratrol is clinically documented to support your cardiovascular health, have an antioxidant effect, reduce inflammation and more.*
3. 5-methyltetrahydrofolate: Promotes healthy DNA methylation. Studies have shown better health where there is normal DNA methylation. 5-methyltetrahydrofolate helps keep your DNA – and you – healthy.*
4. Green tea leaf extract: Best known for its antioxidant properties, green tea leaf extract is recognized for maintaining overall health.*
OptiAge Level 1 contains these four crucial ingredients to help fight the negative effects of aging at the cellular level.* Start improving your health and longevity today!
And for the most complete anti-aging support available, be sure to use OptiAge Level 1 in conjunction with OptiAge Level 2.* See here for more information.
- Abu El Maaty MA, Hanafi RS, El-Badawy S, Gad MZ. Aging Clin Exp Res. 2014 Aug;26(4):363-8.
- Almeida L, Vaz-da-Silva M, Falcão A, Soares E, Costa R, Loureiro AI, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, Soares-da-Silva P. Mol Nutr Food Res. 2009 May;53 Suppl 1:S7-15.
- Aloia JF, Li-Ng M. Epidemiol Infect. 2007 Oct;135(7):1095-6; author reply 1097-8.
- Anderson JL, May HT, Horne BD, Bair TL, Hall NL, Carlquist JF, Lappé DL, Muhlestein JB; Intermountain Heart Collaborative (IHC) Study Group. Am J Cardiol. 2010 Oct 1;106(7):963-8.
- Anton SD, Embry C, Marsiske M, Lu X, Doss H, Leeuwenburgh C, Manini TM. Exp Gerontol. 2014 Sep;57:181-7.
- Armas LA, Hollis BW, Heaney RP. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91.
- Assuncao M, Andrade JP. Front Biosci (Landmark Ed). 2015 Jan 1;20:247-62.
- Bass TM, Weinkove D, Houthoofd K, Gems D, Partridge L. Mech Ageing Dev. 2007 Oct;128(10):546-52.
- Basu A, Betts NM, Mulugeta A, Tong C, Newman E, Lyons TJ. Nutr Res. 2013 Mar;33(3):180-7.
- Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Nature. 2006 Nov 16;444(7117):337-42.
- Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Nutr Res. 2012 Jun;32(6):421-7.
- Borras M, Panizo S, Sarró F, Valdivielso JM, Fernandez E. Clin Ther. 2012 Apr;34(4):849-56.
- Brasnyó P, Molnár GA, Mohás M, Markó L, Laczy B, Cseh J, Mikolás E, Szijártó IA, Mérei A, Halmai R, Mészáros LG, Sümegi B, Wittmann I. Br J Nutr. 2011 Aug;106(3):383-9.
- Brönstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Am J Clin Nutr. 1998 Nov;68(5):1104-10.
- Bryan J, Calvaresi E, Hughes D. J Nutr. 2002 Jun;132(6):1345-56.
- Cao Y, Jones G, Cicuttini F, Winzenberg T, Wluka A, Sharman J, Nguo K, Ding C. Trials. 2012 Aug 6;13:131.
- Choi SW, Yeung VT, Collins AR, Benzie IF. Mutagenesis. 2015 Jan;30(1):129-37.
- Crider KS, Yang TP, Berry RJ, Bailey LB. Adv Nutr. 2012 Jan;3(1):21-38.
- Dawson-Hughes B, Dallal GE, Krall EA, Harris S, Sokoll LJ, Falconer G. Ann Intern Med. 1991 Oct 1;115(7):505-12.
- Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. N Engl J Med. 1997 Sep 4;337(10):670-6.
- Forman JP, Scott JB, Ng K, Drake BF, Suarez EG, Hayden DL, Bennett GG, Chandler PD, Hollis BW, Emmons KM, Giovannucci EL, Fuchs CS, Chan AT. Hypertension. 2013 Apr;61(4):779-85.
- Geusens P, Vanderschueren D, Verstraeten A, Dequeker J, Devos P, Bouillon R. Calcif Tissue Int. 1991 Sep;49(3):168-73.
- Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8.
- Goh KP, Lee HY, Lau DP, Supaat W, Chan YH, Koh AF. Int J Sport Nutr Exerc Metab. 2014 Feb;24(1):2-13.
- Grazio S, Nagli?? ??B, Ani?? B, Grubiši?? F, Bobek D, Bakula M, Kavanagh HS, Kuna AT, Cvijeti?? S. Am J Med Sci. 2015 Jan;349(1):46-9.
- Heaney RP, Barger-Lux MJ, Dowell MS, Chen TC, Holick MF. J Clin Endocrinol Metab. 1997 Dec;82(12):4111-6.
- Heaney RP, Dowell MS, Hale CA, Bendich A. J Am Coll Nutr. 2003 Apr;22(2):142-6.
- Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. J Clin Endocrinol Metab. 2011 Mar;96(3): E447-52.
- Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.
- Itami N, Shirasuna K, Kuwayama T, Iwata H. Theriogenology. 2015 May;83(8):1360-7.
- Kado DM, Karlamangla AS, Huang MH, Troen A, Rowe JW, Selhub J, Seeman TE. Am J Med. 2005 Feb;118(2):161-7.
- Kim YI. J Nutr. 2005 Nov;135(11):2703-9.
- Klaunig JE, Xu Y, Han C, Kamendulis LM, Chen J, Heiser C, Gordon MS, Mohler ER 3rd. Proc Soc Exp Biol Med. 1999 Apr;220(4):249-54.
- Konstari S, Kaila-Kangas L, Jääskeläinen T, Heliövaara M, Rissanen H, Marniemi J, Knekt P, Arokoski J, Karppinen J. Rheumatology (Oxford). 2014 Oct;53(10):1778-82
- Laslett LL, Quinn S, Burgess JR, Parameswaran V, Winzenberg TM, Jones G, Ding C. Ann Rheum Dis. 2014 Apr;73(4):697-703.
- Li-Ng M, Aloia JF, Pollack S, Cunha BA, Mikhail M, Yeh J, Berbari N. Epidemiol Infect. 2009 Oct;137(10):1396-404.
- Liu JJ, Prescott J, Giovannucci E, Hankinson SE, Rosner B, Han J, De Vivo I. Am J Epidemiol. 2013 Jun 15;177(12):1411-7.
- Logan VF, Gray AR, Peddie MC, Harper MJ, Houghton LA. Br J Nutr. 2013 Mar 28;109(6):1082-8.
- Magyar K, Halmosi R, Palfi A, Feher G, Czopf L, Fulop A, Battyany I, Sumegi B, Toth K, Szabados E. Clin Hemorheol Microcirc. 2012;50(3):179-87.
- Malas FU, Kara M, Aktekin L, Ersöz M, Ozçakar L. Clin Rheumatol. 2014 Sep;33(9):1331-4.
- Marcucci R, Zanazzi M, Bertoni E, Rosati A, Fedi S, Lenti M, Prisco D, Castellani S, Abbate R, Salvadori M. Transplantation. 2003 May 15;75(9):1551-5.
- Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, Felsenfeld A, Levine B, Mehrotra R, Norris K. Arch Intern Med. 2007 Jun 11;167(11):1159-65.
- McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, Lo G, Dawson-Hughes B. JAMA. 2013 Jan 9;309(2):155-62.
- Murias M, Handler N, Erker T, Pleban K, Ecker G, Saiko P, Szekeres T, Jäger W. Bioorg Med Chem. 2004 Nov 1;12(21):5571-8.
- Pufulete M, Al-Ghnaniem R, Khushal A, Appleby P, Harris N, Gout S, Emery PW, Sanders TA. Gut. 2005 May;54(5):648-53.
- Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A. Am J Clin Nutr. 2007 Nov;86(5):1420-5.
- Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, Srivastava RN. Clin Orthop Relat Res. 2013 Nov;471(11):3556-62.
- Saposnik G, Ray JG, Sheridan P, McQueen M, Lonn E; Heart Outcomes Prevention Evaluation 2 Investigators. Stroke. 2009 Apr;40(4):1365-72.
- Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. JAMA. 2002 Aug 28;288(8):973-9.
- Seijo M, Mastaglia S, Brito G, Somoza J, Oliveri B. Medicina (B Aires). 2012;72(3):195-200.
- Serafini M, Ghiselli A, Ferro-Luzzi A. Eur J Clin Nutr. 1996 Jan;50(1):28-32.
- Suliburska J, Bogdanski P, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Biol Trace Elem Res. 2012 Dec;149(3):315-22.
- Sun Q, Shi L, Rimm EB, Giovannucci EL, Hu FB, Manson JE, Rexrode KM. Am J Clin Nutr. 2011 Aug;94(2):534-42.
- Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Oncogene. 2004 Dec 9;23(57):9247-58.
- Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P. Cell Metab. 2011 Nov 2;14(5):612-22.
- Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG, Wang CH, Stampfer M. JAMA. 2004 Feb 4;291(5):565-75.
- Trang HM, Cole DE, Rubin LA, Pierratos A, Siu S, Vieth R. Am J Clin Nutr. 1998 Oct;68(4):854-8.
- Triantafyllou NI, Nikolaou C, Boufidou F, Angelopoulos E, Rentzos M, Kararizou E, Evangelopoulos ME, Vassilopoulos D. Parkinsonism Relat Disord. 2008;14(4):321-5.
- Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Am J Clin Nutr. 2010 May;91(5):1255-60.
- van der Griend R, Biesma DH, Haas FJ, Faber JA, Duran M, Meuwissen OJ, Banga JD. J Intern Med. 2000 Sep;248(3):223-9.
- van Oort FV, Melse-Boonstra A, Brouwer IA, Clarke R, West CE, Katan MB, Verhoef P. Am J Clin Nutr. 2003 May;77(5):1318-23.
- Vermeulen EG, Stehouwer CD, Twisk JW, van den Berg M, de Jong SC, Mackaay AJ, van Campen CM, Visser FC, Jakobs CA, Bulterjis EJ, Rauwerda JA. Lancet. 2000 Feb 12;355(9203):517-22.
- Warner AE, Arnspiger SA. J Clin Rheumatol. 2008 Feb;14(1):12-6.
- Weisburger JH. Proc Soc Exp Biol Med. 1999 Apr;220(4):271-5.
- Witham MD, Dove FJ, Dryburgh M, Sugden JA, Morris AD, Struthers AD. Diabetologia. 2010 Oct;53(10):2112-9.
- Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Nutr Metab Cardiovasc Dis. 2011 Nov;21(11):851-6.
- Wu SH, Ho SC, Zhong L. South Med J. 2010 Aug;103(8):729-37.
- Yajnik CS, Lubree HG, Thuse NV, Ramdas LV, Deshpande SS, Deshpande VU, Deshpande JA, Uradey BS, Ganpule AA, Naik SS, Joshi NP, Farrant H, Refsum H. Asia Pac J Clin Nutr. 2007;16(1):103-9.
- Yazaki Y, Chow G, Mattie M. J Altern Complement Med. 2006 Nov;12(9):881-5.
- Zhang FF, Driban JB, Lo GH, Price LL, Booth S, Eaton CB, Lu B, Nevitt M, Jackson B, Garganta C, Hochberg MC, Kwoh K, McAlindon TE. J Nutr. 2014 Dec;144(12):2002-8.
- Zhu H, Guo D, Li K, Pedersen-White J, Stallmann-Jorgensen IS, Huang Y, Parikh S, Liu K, Dong Y. Int J Obes (Lond). 2012 Jun;36(6):805-9.